Conditioned Medium Derived from Notochordal Cell-Rich Nucleus Pulposus Tissue Stimulates Matrix Production by Canine Nucleus Pulposus Cells and Bone Marrow-Derived Stromal Cells

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Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.

OBJECTIVES Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue (NCCM) was previously shown to have a stimulatory effect on bone marrow stromal cells (BMSCs) and nucleus pulposus cells (NPCs) individually, in mixed species in vitro cell models. The objective of the current study was to assess the stimulatory effect of NCCM on NPCs in a homologous canine in vitro model a...

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Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration

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Notochordal cell rich nucleus pulposus tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human MSCs

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ژورنال

عنوان ژورنال: Tissue Engineering Part A

سال: 2015

ISSN: 1937-3341,1937-335X

DOI: 10.1089/ten.tea.2014.0309